Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

Hyung-In Moon; Tae-im Kim; Hyun-Soo Cho; Eung Kweon Kim

doi:10.1016/j.bmcl.2009.12.059

Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida

Bioorg Med Chem Lett. 2010 Feb 1;20(3):991-3. doi: 10.1016/j.bmcl.2009.12.059. Epub 2009 Dec 22.

Authors

Hyung-In Moon¹, Tae-im Kim, Hyun-Soo Cho, Eung Kweon Kim

Affiliation

¹ Inam Neuroscience Research Center, Wonkwang University Sanbon Medical Center, Sanbon-dong, Gunpocity, Kyunggi-Do 435-040, South Korea.

PMID: 20053563
DOI: 10.1016/j.bmcl.2009.12.059

Abstract

Four oligomeric procyanidins were isolated from the MeOH extracts of the leaves of Crataegus pinnatifida (Rosaceae). Investigation of collagenase and gelatinase inhibitory natural components afforded four oligomeric procyanidins. Of these, 2 and 3 exhibited collagenase inhibitory activity (IC(50)) at a concentration of less than 1 microM, and 3 showed gelatinases A and B inhibitory activity (IC(50)) at 0.4 and 2.3 microM, respectively.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Collagenases / metabolism
Crataegus*
Gelatinases / antagonists & inhibitors*
Gelatinases / metabolism
Humans
Matrix Metalloproteinase Inhibitors*
Plant Extracts / chemistry*
Plant Extracts / isolation & purification
Plant Extracts / pharmacology*
Plant Leaves

Substances

Matrix Metalloproteinase Inhibitors
Plant Extracts
Collagenases
Gelatinases